Principal Scientist Job at Scorpion Therapeutics, San Diego, CA

  • Scorpion Therapeutics
  • San Diego, CA

Job Description

Role:

Principal Scientist leading antibody engineering initiatives within Bristol Myers Squibb's Therapeutic Discovery Sciences Department, focusing on early-stage research and platform technology development for recombinant antibody therapeutics.

Responsibilities:
  • design, execute, and troubleshoot workflows for affinity maturation, humanization, format conversion, and characterization of diverse antibody formats (IgG, Fab, scFv, bispecifics)
  • analyze biophysical properties using SEC, SPR/BLI
  • collaborate across discovery, structural biology, computational biology, and other teams
  • evaluate emerging technologies including AI/ML
  • author technical documentation and lead scientific discussions.
Requirements:
  • PhD in protein science, structural biology, biochemistry, or related field
  • 4+ years of relevant industry or academic experience
  • hands-on expertise in antibody design, expression, purification, and characterization
  • experience with protein interaction assays like SPR/BLI
  • proven independent experiment planning and troubleshooting skills
  • scientific leadership with impactful publications or patents.
Preferred:
  • experience with advanced antibody formats, bioinformatics, structural techniques, and therapeutic areas such as oncology or immunology
  • prior biotech or pharma experience.
HighValue:
  • biologics
  • antibody engineering
  • early discovery
  • biophysical characterization
  • platform development
  • cross-disciplinary collaboration.
Work setup:

laboratory-based role in San Diego, CA.

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